Father Samuel Mazzuchelli was born in Milan, Italy and entered the Dominican Order of Preachers in 1830. He came to the American frontier as a missionary and was assigned to the Northwest Territory (Middle America). As a teacher and preacher, he ministered to the immigrants and native American tribes, some hadn't seen a priest for 50-100 years, and he then administered the sacraments to them. The Sinsinawa Dominican Sisters were also founded by him. As a talented architect, he designed and built more than 24 churches and civic buildings before his death at 57 from pneumonia.